靶标：
RANBP2
产品别名：
ADANE； ANE1； IIAE3； NUP358； TRP1； TRP2； RANBP2； RAN binding protein 2； RAN binding protein 2； E3 SUMO-protein ligase RanBP2； 358 kDa nucleoporin； E3 SUMO-protein transferase RanBP2； P270； acute necrotizing encephalopathy 1 (autosomal dominant)； nuclear pore complex protein Nup358； nucleoporin 358； nucleoporin Nup358； ran-binding protein 2； transformation-related protein 2； RAN结合蛋白2/核孔蛋白；
背景信息：
RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008],
宿主：Rbt
类型：Pab
同种型:IgG
应用：WB
纯化方式：亲和纯化
偶联物：Unconjugated
性状：液体
存储溶液：参阅说明书
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
稀释比例: Optimal dilutions/concentrations should be determined by the end user
储存：经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
