靶标：
RRBP1
产品别名：
ES/130； ES130； RRp； hES； p180； RRBP1； ribosome binding protein 1； ribosome binding protein 1； ribosome-binding protein 1； 180 kDa ribosome receptor homolog； ES/130-related protein； endoplasmic reticulum ribosome-binding protein 1； ribosomal receptor-binding protein 1； ribosome binding protein 1 homolog 180kDa (dog)； ribosome receptor protein； 核糖体结合蛋白1；
背景信息：
This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12. [provided by RefSeq, Apr 2012],
