靶标：
CCL22
产品别名：
A-152E5.1； ABCD-1； DC/B-CK； MDC； SCYA22； STCP-1； CCL22； C-C motif chemokine ligand 22； C-C motif chemokine ligand 22； C-C motif chemokine 22； CC chemokine STCP-1； MDC(1-69)； chemokine (C-C motif) ligand 22； macrophage-derived chemokine； small inducible cytokine A22； small inducible cytokine subfamily A (Cys-Cys), member 22； stimulated T cell chemotactic protein 1； 嗜酸粒细胞趋化蛋白22； 巨噬细胞来源趋化因子(MDC)；
背景信息：
function:May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.,online information:CCL22 entry,PTM:The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes.,similarity:Belongs to the intercrine beta (chemokine CC) family.,tissue specificity:Highly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. Also found in lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression in lung and spleen. Very weak expression in small intestine. In lymph node expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Expressed in Langerhans' cell histiocytosis but not in dermatopathic lymphadenopathy. Expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the eptdermis and dermis.,
