靶标：
SDHC
产品别名：
CYB560； CYBL； PGL3； QPS1； SDH3； SDHC； succinate dehydrogenase complex subunit C； succinate dehydrogenase complex subunit C； succinate dehydrogenase cytochrome b560 subunit, mitochondrial； cytochrome B large subunit of complex II； integral membrane protein CII-3b； large subunit of cytochrome b； succinate dehydrgenase cytochrome b； succinate dehydrogenase 3, integral membrane subunit； succinate dehydrogenase complex subunit C integral membrane protein 15kDa； succinate dehydrogenase complex, subunit C, integral membrane protein, 15kD； succinate-ubiquinone oxidoreductase cytochrome B large subunit； 琥珀酸细胞色素亚基B560； 琥珀酸脱氢酶复合体C亚基(SDHC)；
背景信息：
SDHC(succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa) also known as SDH3, SUCCINATE DEHYDROGENASE CYTOCHROME b. The SDHC gene contains 6 exons. Oostveen et al.(1995) found that in fact it was protein from the bovine SDH3 gene(encoding 1 of the 2 integral membrane proteins) that complemented the hamster mutation. The authors localized the human SDH3 gene to the short arm of chromosome one, within 1 to 2 Mb from the centromere. Additionally, the authors stated that Southern analyses of human genomic DNA suggested that there are multiple SDH3 genes or pseudogenes. Elbehti-Green et al.(1998)°Confirmed the assignment of the SDHC gene to 1q21 by FISH. Baysal et al.(2004) described a family with PGL3 in which an 8,372-bp deletion in the SDHC gene was transmitted both maternally and paternally, without evidence of genomic imprinting.
