靶标：
SIPA1
产品别名：
SPA1； SIPA1； signal-induced proliferation-associated 1； signal-induced proliferation-associated 1； signal-induced proliferation-associated protein 1； GTPase-activating protein Spa-1； p130 SPA-1； signal-induced proliferation-associated gene 1； sipa-1； 信号感应增殖相关蛋白1； 信号诱导增殖相关蛋白1；
背景信息：
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.
