靶标:
SLC1A4
产品别名:
ASCT1; SATT; SPATCCM; SLC1A4; solute carrier family 1 member 4; solute carrier family 1 member 4; neutral amino acid transporter A; alanine/serine/cysteine/threonine transporter 1; glutamate/neutral amino acid transporter; solute carrier family 1 (glutamate/neutral amino acid transporter), member 4; 溶质载体家族蛋白1成员A4;
背景信息:
SLC1A4(也称 ASCT1)是一种中性氨基酸转运体。它也被命名为 ASCT1,原因是它能介导丙氨酸、丝氨酸、半胱氨酸和苏氨酸的固性交换 (1)。SLC1A4 能介导谷氨酸通过钙依赖性释放从神经元流入突触连接,同时还能介导 L 丝氨酸从胶质细胞流出及其神经元摄取 (2)。SLC1A4 介导的转运经证实参与中性氨基酸和钠离子之间对称性钾离子非依赖的电中性交换,例如转运期间的激活电流仅由氯离子运载 (3)。