靶标：
SORD
产品别名：
HEL-S-95n； RDH； SDH； SORD1； SORDD； XDH； SORD； sorbitol dehydrogenase； sorbitol dehydrogenase； sorbitol dehydrogenase； (R,R)-butanediol dehydrogenase； L-iditol 2-dehydrogenase； epididymis secretory sperm binding protein Li 95n； polyol dehydrogenase； ribitol dehydrogenase； xylitol dehydrogenase； 山梨醇脱氢酶； 山梨醇脱氢酶(SDH)；
背景信息：
Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010],
