靶标：
SREBF1
产品别名：
HMD； IFAP2； SREBP1； bHLHd1； SREBF1； sterol regulatory element binding transcription factor 1； sterol regulatory element binding transcription factor 1； sterol regulatory element-binding protein 1； class D basic helix-loop-helix protein 1； 固醇调节元件结合转录因子1(SREBF1)； 胆固醇调节元件结合蛋白1；
背景信息：
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Mar 2016],
