靶标:
SRY
产品别名:
SRXX1; SRXY1; TDF; TDY; SRY; sex determining region Y; sex determining region Y; sex-determining region Y protein; essential protein for sex determination in human males; sex-determining region on Y; testis-determining factor on Y; 性别决定区Y(SRY);
背景信息:
This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008],