靶标:
HNF1B
产品别名:
ADTKD3; FJHN; HNF-1-beta; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3; LFB3; MODY5; RCAD; T2D; TCF-2; TCF2; VHNF1; HNF1B; HNF1 homeobox B; HNF1 homeobox B; hepatocyte nuclear factor 1-beta; HNF1 beta A; homeoprotein LFB3; transcription factor 2, hepatic; 肝细胞核因子1β(HNF1b); 肝细胞核因子1β/HNF-1β;
背景信息:
This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009],