靶标：
TLE2
产品别名：
ESG； ESG2； GRG2； TLE2； TLE family member 2, transcriptional corepressor； TLE family member 2, transcriptional corepressor； transducin-like enhancer protein 2； enhancer of split groucho-like protein 2； transducin like enhancer of split 2； transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)； transducin-like enhancer of split 2, homolog of Drosophila E(sp1)；
背景信息：
function:Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.,similarity:Belongs to the WD repeat Groucho/TLE family.,similarity:Contains 6 WD repeats.,subunit:Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 and HES5.,tissue specificity:In all tissues examined, mostly in heart, brain, and muscle.,
