靶标：
TLE4
产品别名：
BCE-1； BCE1； E(spI)； E(spl)； ESG； ESG4； GRG4； Grg-4； TLE4； TLE family member 4, transcriptional corepressor； TLE family member 4, transcriptional corepressor； transducin-like enhancer protein 4； B lymphocyte gene 1； enhancer of split groucho 4； groucho-related protein 4； transducin like enhancer of split 4； transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)； transducin-like enhancer of split 4, homolog of Drosophila E(sp1)； B淋巴细胞基因1；
背景信息：
caution:Product of a dubious CDS prediction. Found in the 3'UTR of TLE4. No homolog. Large scale identification of a phosphorylated peptide (PubMed:15302935) would require further confirmation.,function:Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.,similarity:Belongs to the WD repeat Groucho/TLE family.,similarity:Contains 7 WD repeats.,subunit:Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2.,tissue specificity:In all tissues examined, mostly in brain, and muscle.,
