靶标:
WARS1
产品别名:
GAMMA-2; HMN9; IFI53; IFP53; WARS; WARS1; tryptophanyl-tRNA synthetase 1; tryptophanyl-tRNA synthetase 1; tryptophan--tRNA ligase, cytoplasmic; epididymis secretory sperm binding protein; hWRS; interferon-induced protein 53; trpRS; tryptophan tRNA ligase 1, cytoplasmic; 色氨酰tRNA合成酶(WARS);
背景信息:
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene.