靶标：
ZFAND5
产品别名：
ZA20D2； ZFAND5A； ZNF216； ZFAND5； zinc finger AN1-type containing 5； zinc finger AN1-type containing 5； AN1-type zinc finger protein 5； zinc finger A20 domain-containing protein 2； zinc finger protein 216； zinc finger, A20 domain containing 2； zinc finger, AN1-type domain 5； AN1型锌指蛋白5；
背景信息：
Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF, IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.
