靶标：
PIP5K1B
产品别名：
MSS4； STM7； PIP5K1B； phosphatidylinositol-4-phosphate 5-kinase type 1 beta； phosphatidylinositol-4-phosphate 5-kinase type 1 beta； phosphatidylinositol 4-phosphate 5-kinase type-1 beta； PIP5K1-beta； PIP5KIbeta； phosphatidylinositol 4-phosphate 5-kinase type I beta； protein STM-7； ptdIns(4)P-5-kinase 1 beta； type I phosphatidylinositol 4-phosphate 5-kinase beta；
背景信息：
Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4P/PI4P to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5P2/PIP2, a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (By similarity. PtdIns(4,5P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3, diacylglycerol (DAG or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5P3/PIP3 (By similarity. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity.
