靶标:
DYRK3
产品别名:
DYRK5; RED; REDK; hYAK3-2; DYRK3; dual specificity tyrosine phosphorylation regulated kinase 3; dual specificity tyrosine phosphorylation regulated kinase 3; dual specificity tyrosine-phosphorylation-regulated kinase 3; dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 5; protein kinase Dyrk3; regulatory erythroid kinase; 双特异性酪氨酸调节激酶3;
背景信息:
This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],