靶标：
AKR1C3
产品别名：
DD3； DDX； HA1753； HAKRB； HAKRe； HSD17B5； PGFS； hluPGFS； AKR1C3； aldo-keto reductase family 1 member C3； aldo-keto reductase family 1 member C3； aldo-keto reductase family 1 member C3； 3-alpha hydroxysteroid dehydrogenase, type II； 3-alpha-HSD type II, brain； chlordecone reductase homolog HAKRb； dihydrodiol dehydrogenase 3； dihydrodiol dehydrogenase X； indanol dehydrogenase； prostaglandin F synthase； testosterone 17-beta-dehydrogenase 5； trans-1,2-dihydrobenzene-1,2-diol dehydrogenase； type IIb 3-alpha hydroxysteroid dehydrogenase； 醛固酮还原酶家族1成员C3；
背景信息：
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
