靶标:
ABCB11
产品别名:
ABC16; BRIC2; BSEP; PFIC-2; PFIC2; PGY4; SPGP; ABCB11; ATP binding cassette subfamily B member 11; ATP binding cassette subfamily B member 11; bile salt export pump; ABC member 16, MDR/TAP subfamily; ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; progressive familial intrahepatic cholestasis 2; sister p-glycoprotein; ATP结合盒转运蛋白B11(ABCB11); 胆汁酸盐输出泵;
背景信息:
催化主要的疏水性胆汁盐(例如牛磺酸和甘氨酸缀合的胆酸)以ATP依赖性方式穿过肝细胞的小管膜,因此参与肝胆汁酸的稳态,因此通过调节胆汁脂质的分泌参与脂质的稳态 以胆汁盐依赖的方式。 牛磺酸结合的胆汁盐比甘氨酸结合的胆汁盐更快地运输。