靶标:
RIPK2
产品别名:
CARD3; CARDIAK; CCK; GIG30; RICK; RIP2; RIPK2; receptor interacting serine/threonine kinase 2; receptor interacting serine/threonine kinase 2; receptor-interacting serine/threonine-protein kinase 2; CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; RIP-2; growth-inhibiting gene 30; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; receptor-interacting protein 2; tyrosine-protein kinase RIPK2; 受体相互作用丝氨酸苏氨酸激酶2(RIPK2); 受体结合丝氨酸苏氨酸激酶2;
背景信息:
受体互作蛋白 2 (RIP2) 是一个丝氨酸/苏氨酸激酶,有一个羧基末端 caspase 激活和募集结构域 (CARD)。RIP2 结合肿瘤坏死因子受体 (TNFR) 会激活 NF-kB 并诱导细胞凋亡 (1-3)。暴露在 LPS 等细菌细胞壁组分中会诱导巨噬细胞中的 RIP2 表达。RIP2 缺失型小鼠模型表明,这种激酶会整合并转导先天和适应性免疫系统的信号 (4,5)。