靶标：
DPM1
产品别名：
CDGIE； MPDS； DPM1； dolichyl-phosphate mannosyltransferase subunit 1, catalytic； dolichyl-phosphate mannosyltransferase subunit 1, catalytic； dolichol-phosphate mannosyltransferase subunit 1； DPM synthase complex, catalytic subunit； DPM synthase subunit 1； MPD synthase subunit 1； dolichol monophosphate mannose synthase； dolichol-phosphate mannose synthase subunit 1； dolichyl-phosphate beta-D-mannosyltransferase subunit 1； dolichyl-phosphate mannosyltransferase polypeptide 1 catalytic subunit； mannose-P-dolichol synthase subunit 1； DPM1蛋白；
背景信息：
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants.
