靶标:
PER2
产品别名:
FASPS; FASPS1; PER2; period circadian regulator 2; period circadian regulator 2; period circadian protein homolog 2; circadian clock protein PERIOD 2; hPER2; period 2; period circadian clock 2; period circadian protein 2; period homolog 2; 昼夜节律蛋白2(PER2); 节律蛋白2;
背景信息:
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014],