靶标：
SKAP2
产品别名：
PRAP； RA70； SAPS； SCAP2； SKAP-HOM； SKAP55R； SKAP2； src kinase associated phosphoprotein 2； src kinase associated phosphoprotein 2； src kinase-associated phosphoprotein 2； Fyn-associated phosphoprotein SKAP55 homologue； Pyk2/RAFTK-associated protein； SKAP-55HOM； SKAP55 homolog； retinoic acid-induced protein 70； src family-associated phosphoprotein 2； src kinase-associated phosphoprotein of 55-related protein； src-associated adapter protein with PH and SH3 domains； Src家族相关蛋白2；
背景信息：
Src kinase-associated phosphoprotein 2 is an enzyme that in humans is encoded by the SKAP2 gene. The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms.
