靶标：
UBA3
产品别名：
NAE2； UBE1C； hUBA3； UBA3； ubiquitin like modifier activating enzyme 3； ubiquitin like modifier activating enzyme 3； NEDD8-activating enzyme E1 catalytic subunit； NEDD8-activating enzyme E1 subunit 2； NEDD8-activating enzyme E1C； Nedd8-activating enzyme hUba3； UBA3, ubiquitin-activating enzyme E1 homolog； ubiquitin-activating enzyme 3； ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)； ubiquitin-activating enzyme E1C (homologous to yeast UBA3)；
背景信息：
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
