靶标：
USP2
产品别名：
UBP41； USP9； USP2； ubiquitin specific peptidase 2； ubiquitin specific peptidase 2； ubiquitin carboxyl-terminal hydrolase 2； 41 kDa ubiquitin-specific protease； deubiquitinating enzyme 2； ubiquitin specific protease 12； ubiquitin specific protease 9； ubiquitin thioesterase 2； ubiquitin-specific-processing protease 2；
背景信息：
This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
