靶标：
ATP6V0D1
产品别名：
ATP6D； ATP6DV； P39； VATX； VMA6； VPATPD； ATP6V0D1； ATPase H+ transporting V0 subunit d1； ATPase H+ transporting V0 subunit d1； V-type proton ATPase subunit d 1； 32 kDa accessory protein； ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D； ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1； H(+)-transporting two-sector ATPase, subunit D； V-ATPase 40 KDa accessory protein； V-ATPase AC39 subunit； V-ATPase subunit d 1； V-ATPase, subunit D； vacuolar proton pump subunit d 1；
背景信息：
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. [pro
