靶标：
LRRFIP2
产品别名：
HUFI-2； LRRFIP2； LRR binding FLII interacting protein 2； LRR binding FLII interacting protein 2； leucine-rich repeat flightless-interacting protein 2； LRR FLII-interacting protein 2； leucine rich repeat (in FLII) interacting protein 2； LRRFIP2蛋白；
背景信息：
The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex.
