靶标：
NOLC1
产品别名：
NOPP130； NOPP140； NS5ATP13； P130； Srp40； NOLC1； nucleolar and coiled-body phosphoprotein 1； nucleolar and coiled-body phosphoprotein 1； nucleolar and coiled-body phosphoprotein 1； 140 kDa nucleolar phosphoprotein； HCV NS5A trans-regulated protein 13； HCV NS5A-transactivated protein 13； hepatitis C virus NS5A-transactivated protein 13； nucleolar 130 kDa protein； nucleolar and coiled-body phosphprotein 1； nucleolar phosphoprotein p130； nucleolar protein p130； 丙型肝炎病毒NS5A反式蛋白13； 核仁连续体磷蛋白1(NOLC1)；
背景信息：
function:Related to nucleologenesis, may play a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It has intrinsic GTPase and ATPase activities. May play an important role in transcription catalyzed by RNA polymerase I.,PTM:Undergoes rapid and massive phosphorylation/dephosphorylation cycles on CK2 and PKC sites. There is evidence suggesting that CDC2 kinase phosphorylates p130 at the M-phase.,similarity:Contains 1 LisH domain.,subcellular location:Shuttles between the nucleolus and the cytoplasm. At telophase it begins to assemble into granular-like pre-nucleolar bodies which are subsequently relocated to nucleoli at the early G1-phase.,subunit:Interacts with RNA polymerase I 194 kDa subunit (RPA194) and with casein kinase-II.,
