靶标：
TRIP4
产品别名：
ASC-1； ASC1； HsT17391； MDCDC； SMABF1； ZC2HC5； TRIP4； thyroid hormone receptor interactor 4； thyroid hormone receptor interactor 4； activating signal cointegrator 1； TR-interacting protein 4； TRIP-4； thyroid receptor-interacting protein 4； zinc finger, C2HC5-type； 甲状腺激素受体相互作用蛋白4；
背景信息：
This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1). [provided by RefSeq, Apr 2016],
