靶标：
MED17
产品别名：
CRSP6； CRSP77； DRIP80； SRB4； TRAP80； MED17； mediator complex subunit 17； mediator complex subunit 17； mediator of RNA polymerase II transcription subunit 17； ARC77； CRSP complex subunit 6； activator-recruited cofactor 77 kDa component； cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa； epididymis secretory sperm binding protein； thyroid hormone receptor-associated protein complex 80 kDa component； transcriptional coactivator CRSP77； vitamin D3 receptor-interacting protein complex 80 kDa component；
背景信息：
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008],
