靶标：
MED27
产品别名：
CRAP34； CRSP34； CRSP8； MED3； NEDSCAC； TRAP37； MED27； mediator complex subunit 27； mediator complex subunit 27； mediator of RNA polymerase II transcription subunit 27； CRSP complex subunit 8； cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa； epididymis secretory sperm binding protein； p37 TRAP/SMCC/PC2 subunit； transcriptional coactivator CRSP34； 转录激活蛋白CRSP8；
背景信息：
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011],
