靶标：
ADAMTS2
产品别名：
ADAM-TS2； ADAMTS-2； ADAMTS-3； EDSDERMS； NPI； PC I-NP； PCI-NP； PCINP； PCPNI； PNPI； ADAMTS2； ADAM metallopeptidase with thrombospondin type 1 motif 2； ADAM metallopeptidase with thrombospondin type 1 motif 2； A disintegrin and metalloproteinase with thrombospondin motifs 2； a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2； procollagen I N-proteinase； procollagen I/II amino propeptide-processing enzyme； procollagen N-endopeptidase； 整合素样金属蛋白酶与凝血酶2型； 血小板反应蛋白解整合素金属肽酶2(ADAMTS2)；
背景信息：
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature procollagen N-proteinase. This proteinase excises the N-propeptide of the fibrillar procollagens types I-III and type V. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically
