靶标：
EEF1E1
产品别名：
AIMP3； P18； EEF1E1； eukaryotic translation elongation factor 1 epsilon 1； eukaryotic translation elongation factor 1 epsilon 1； eukaryotic translation elongation factor 1 epsilon-1； ARS-interacting multifunctional protein 3； aminoacyl tRNA synthetase complex-interacting multifunctional protein 3； multisynthase complex auxiliary component p18； multisynthetase complex auxiliary component p18； p18 component of aminoacyl-tRNA synthetase complex； 抑癌蛋白AIMP3； 真核翻译延伸因子1ε1(EEF1e1)；
背景信息：
This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2.
