靶标：
AKAP12
产品别名：
AKAP250； SSeCKS； AKAP12； A-kinase anchoring protein 12； A-kinase anchoring protein 12； A-kinase anchor protein 12； A kinase (PRKA) anchor protein 12； A-kinase anchor protein, 250kDa； AKAP 250； Src-Suppressed C Kinase Substrate； kinase scaffold protein gravin； myasthenia gravis autoantigen gravin； 丝氨酸抑制蛋白激酶C底物； 激酶锚定蛋白12(AKAP12)；
背景信息：
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
