靶标：
RNF7
产品别名：
CKBBP1； ROC2； SAG； rbx2； RNF7； ring finger protein 7； ring finger protein 7； RING-box protein 2； CKII beta-binding protein 1； regulator of cullins 2； sensitive to apoptosis gene protein； sensitive to apoptosis zinc RING finger protein SAG； sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2； zinc RING finger protein SAG； 环指蛋白7；
背景信息：
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.
