靶标：
ESPL1
产品别名：
ESP1； SEPA； ESPL1； extra spindle pole bodies like 1, separase； extra spindle pole bodies like 1, separase； separin； caspase-like protein ESPL1； extra spindle pole bodies 1, separase； extra spindle pole bodies homolog 1； extra spindle poles like 1； extra spindle poles-like 1 protein； separin, cysteine protease； 外纺锤体极样蛋白1；
背景信息：
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010],
