Rubimaillin (Mollugin) is a naturally occuring naphthohydroquinone extracted from Rubia cordifolia L. with anticancer activity. It acts as a potent and dual inhibitor of ACAT1 and ACAT2, also a modulator of the HER2 pathway, and an inhibitor of TNF-α-induced NF-κB activation. Thus it may be used in the treatment and prevention of human breast and ovarian Y with HER2 overexpression. In addition to the anticancer effects, Rubimaillin may be used as a JAK2 inhibitor that inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. It has the potential to be used for bone loss-associated disorders including osteoporosis, rheumatoid arthritis, and periodontitis.

纯度：≥98%

CAS：55481-88-4