靶标：
HIPK3
产品别名：
DYRK6； FIST3； PKY； YAK1； HIPK3； homeodomain interacting protein kinase 3； homeodomain interacting protein kinase 3； homeodomain-interacting protein kinase 3； ANPK； FIST； androgen receptor-interacting nuclear protein kinase； fas-interacting serine/threonine-protein kinase； homolog of protein kinase YAK1； Fas相互作用蛋白激酶3；
背景信息：
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors.,PTM:Autophosphorylated, but autophosphorylation is not required for catalytic activity.,PTM:May be sumoylated.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with Nkx1-2. Interacts with FAS and DAXX. Probably part of a complex consisting of HIPK3, FAS and FADD. Interacts with and stabilizes ligand-bound androgen receptor (AR) (By similarity). Interacts with UBL1/SUMO-1.,tissue specificity:Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung.,
