靶标：
ABI2
产品别名：
ABI-2； ABI2B； AIP-1； AIP1； AblBP3； SSH3BP2； argBP1； argBPIA； argBPIB； ABI2； abl interactor 2； abl interactor 2； abl interactor 2； abelson interactor 2； abl binding protein 3； abl-interacting protein 1 (SH3-containing protein)； abl-interactor protein 2b； arg protein tyrosine kinase-binding protein； arg-binding protein 1； 肿瘤抑制基因ABI2/精氨酸酪氨酸蛋白激酶结合蛋白；
背景信息：
ABI2(ABL Interactor 2), is a protein that in humans is encoded by the ABI2 gene. By analysis of a YAC and a BAC, Machado et al.(2000) mapped the ABI2 gene to 2q31-q33. ABI2 possesses a basic N terminus with homology to a homeodomain protein; a central serine-rich region; 3 PEST sequences, which are implicated in susceptibility to protein degradation; several proline-rich stretches; and an acidic C terminus with multiple phosphorylation sites and an SH3 domain. Dai and Pendergast(1995) suggested that the ABI proteins may function to coordinate the cytoplasmic and nuclear functions of the ABL1 tyrosine kinase.
