靶标:
NET1
产品别名:
ARHGEF8; NET1A; NET1; neuroepithelial cell transforming 1; neuroepithelial cell transforming 1; neuroepithelial cell-transforming gene 1 protein; Rho guanine nucleotide exchange factor (GEF) 8; epididymis secretory sperm binding protein; guanine nucleotide regulatory protein (oncogene); neuroepithelioma transforming gene 1; p65 Net1 proto-oncogene protein; small GTP-binding protein regulator; 去甲肾上腺素转运蛋白/神经递质去甲肾上腺素转运体; 神经上皮细胞转化基因1; 神经上皮细胞转化基因1(NET1);
背景信息:
This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012],