靶标：
ERN2
产品别名：
IRE1-BETA； IRE1b； IRE2p； hIRE2p； ERN2； endoplasmic reticulum to nucleus signaling 2； endoplasmic reticulum to nucleus signaling 2； serine/threonine-protein kinase/endoribonuclease IRE2； ER to nucleus signalling 2； IRE1 beta； IRE1, S. cerevisiae, homolog of； endoplasmic reticulum to nucleus signalling 2； inositol-requiring 1 beta； inositol-requiring protein 2；
背景信息：
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:The kinase domain is activated by trans-autophosphorylation. Kinase activity is required for activation of the endoribonuclease domain.,function:Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.,similarity:Contains 1 KEN domain.,similarity:Contains 1 protein kinase domain.,
