靶标:
SLCO1B1
产品别名:
HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2; OATPC; SLC21A6; SLCO1B1; solute carrier organic anion transporter family member 1B1; solute carrier organic anion transporter family member 1B1; solute carrier organic anion transporter family member 1B1; OATP-2; liver-specific organic anion transporter 1; sodium-independent organic anion-transporting polypeptide 2; solute carrier family 21 (organic anion transporter), member 6; 肝特异性有机阴离子转运蛋白LST1;
背景信息:
This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009],