靶标:
TAF6L
产品别名:
PAF65A; TAF6L; TATA-box binding protein associated factor 6 like; TATA-box binding protein associated factor 6 like; TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L; PAF65-alpha; PCAF-associated factor 65-alpha; TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa; p300/CBP-associated factor (PCAF)-associated factor 65;
背景信息:
作为PCAF复合体的一个组件,PCAF复合体能够在核体环境中有效地乙酰化组蛋白。PCAF复合体可被认为是酵母SAGA复合体的人类版本。TAF5L作为体细胞重编程所必需的表观遗传调节器。通过H3K9ac沉积和MYC的招募来调节靶基因,从而触发MYC调控网络,从而协调基因表达程序来控制胚胎干细胞状态。与MYC通过RNA聚合酶Ⅱ暂停释放激活靶基因表达的功能。