靶标：
OGA
产品别名：
MEA5； MGEA5； NCOAT； OGA； O-GlcNAcase； O-GlcNAcase； protein O-GlcNAcase； N-acetyl-beta-D-glucosaminidase； N-acetyl-beta-glucosaminidase； beta-N-acetylglucosaminidase； beta-N-acetylhexosaminidase； beta-hexosaminidase； bifunctional protein NCOAT； hyaluronidase in meningioma； meningioma expressed antigen 5 (hyaluronidase)； meningioma-expressed antigen 5； nuclear cytoplasmic O-GlcNAcase and acetyltransferase； 脑膜瘤表达抗原5(MGEA5)；
背景信息：
Protein O-GlcNAcase (EC 3.2.1.169, OGA, glycoside hydrolase O-GlcNAcase, O-GlcNAcase, BtGH84, O-GlcNAc hydrolase) is an enzyme with systematic name (protein)-3-O-(N-acetyl-D-glucosaminyl)-L-serine/threonine N-acetylglucosaminyl hydrolase. The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications.
