靶标：
PPP1R13L
产品别名：
IASPP； NKIP1； RAI； RAI4； PPP1R13L； protein phosphatase 1 regulatory subunit 13 like； protein phosphatase 1 regulatory subunit 13 like； relA-associated inhibitor； NFkB interacting protein 1； PPP1R13B-like protein； inhibitor of ASPP protein； inhibitor of apoptosis stimulating protein of p53； protein iASPP； protein phosphatase 1, regulatory (inhibitor) subunit 13 like； retinoic acid induced 4； 凋亡抑制因子IASPP；
背景信息：
RelA-associated inhibitor is a protein that in humans is encoded by the PPP1R13L gene. Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. Interacts with RELA NF-kappa-B subunit and with SP1 via its C-terminus part. Interacts with p53/TP53, TP63 and TP73.
