靶标:
SUB1
产品别名:
P15; PC4; p14; SUB1; SUB1 regulator of transcription; SUB1 regulator of transcription; activated RNA polymerase II transcriptional coactivator p15; SUB1 homolog, transcriptional regulator; activated RNA polymerase II transcription cofactor 4; positive cofactor 4; 正辅因子4;
背景信息:
Activated RNA polymerase II transcriptional coactivator p15, also known as positive cofactor 4 (PC4) or SUB1 homolog, is a protein that in humans is encoded by the SUB1 gene. This gene is mapped to 5p13.3. The transcriptional cofactor PC4 is an ancient single-strand DNA (ssDNA)-binding protein that has a homologue in bacteriophage T5 where it is likely the elusive replicative ssDNA-binding protein. The recombinant PC4 is shown to function identically to the native protein through its interaction with TAFs.