靶标：
LILRB3
产品别名：
CD85A； HL9； ILT-5； ILT5； LILRA6； LIR-3； LIR3； PIR-B； PIRB； LILRB3； leukocyte immunoglobulin like receptor B3； leukocyte immunoglobulin like receptor B3； leukocyte immunoglobulin-like receptor subfamily B member 3； CD85 antigen-like family member A； immunoglobulin-like transcript 5； leucocyte Ig-like receptor B3； leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6； leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3； monocyte inhibitory receptor HL9； 白细胞免疫球蛋白样受体-B； 白细胞免疫球蛋白样受体亚家族B成员3(LILRB3)；
背景信息：
LILRB3 is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. Leukocyte Immunoglobulin Like Receptor B3 belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
