靶标:
LILRA3
产品别名:
CD85E; HM31; HM43; ILT-6; ILT6; LIR-4; LIR4; LILRA3; leukocyte immunoglobulin like receptor A3; leukocyte immunoglobulin like receptor A3; leukocyte immunoglobulin-like receptor subfamily A member 3; CD85 antigen-like family member E; immunoglobulin-like transcript 6; leucocyte Ig-like receptor A3; leukocyte immunoglobulin-like receptor 4; leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3; monocyte inhibitory receptor HM43/HM31; 白细胞免疫球蛋白样受体亚家族A成员3(LILRA3);
背景信息:
Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function. LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3) lacks a transmembrane region and is presumed to be a soluble receptor.