靶标:
WWP2
产品别名:
AIP2; WWp2-like; WWP2; WW domain containing E3 ubiquitin protein ligase 2; WW domain containing E3 ubiquitin protein ligase 2; NEDD4-like E3 ubiquitin-protein ligase WWP2; HECT-type E3 ubiquitin transferase WWP2; atrophin-1 interacting protein 2; 含WW域E3泛素蛋白连接酶2(WWP2);
背景信息:
This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10.