靶标：
ADAMTS5
产品别名：
ADAM-TS 11； ADAM-TS 5； ADAM-TS5； ADAMTS-11； ADAMTS-5； ADAMTS11； ADMP-2； ADAMTS5； ADAM metallopeptidase with thrombospondin type 1 motif 5； ADAM metallopeptidase with thrombospondin type 1 motif 5； A disintegrin and metalloproteinase with thrombospondin motifs 5； a disintegrin and metalloproteinase with thrombospondin motifs 11； a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)； aggrecanase-2； 血小板反应蛋白解整合素金属肽酶5(ADAMTS5)； 软骨蛋白聚糖；
背景信息：
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016],
