靶标：
ECD
产品别名：
GCR2； HSGT1； SGT1； ECD； ecdysoneless cell cycle regulator； ecdysoneless cell cycle regulator； protein ecdysoneless homolog； ecdysoneless homolog； human suppressor of GCR two； protein SGT1； suppressor of GCR2； suppressor of S. cerevisiae gcr2； SGT1蛋白；
背景信息：
Protein SGT1 is a protein that in humans is encoded by the ECD gene. Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing.
